Structural Physiology (Medical School, U Tokyo) Sho Yagishita
International Research Institute for Neurointelligence (IRCN, U Tokyo) Haruo Kasai
We have revealed that our mind is shaped by motility of synaptic connections , and unravel the mysteries of our mind and mental disorders.
How does learning occur and memory is stored in the brain? In the cerebrum, excitatory synapses are formed on tiny spiny protrusions of dendrites called dendritic spines. We developed optical manipulation of synapses even before optogenetics, and have revealed that dendritic spines show a structure-function relationship, rapid enlargement for LTP, time-dependent modulation by dopamine, slow fluctuations to manage memory, and physic act on presynaptic terminals. We also developed optical labeling and interrogation of active synapses in vivo. These spine dynamics must underlie cognitive functions such as perception, attention, emotion, decision- making, and planning. In mental disorders, such as schizophrenia, autism, depression, drug addiction, and dementia, impairments of spine function lead to deficits in cognitive and subjective functions. We are currently studying the ultimate mysteries of the brain.
May 1, 2023
Dr. Shiki Zhu jointed as a research fellow.
March 17, 2023
Our new review on Mechanical transmission at spine synapse has been published.
January 21, 2023
Mr. Takayoshi Ohkubo (M1 student) jointed Yagishita G.
January 4, 2023
December 1, 2022
Dr. Daria Sharapova joined Yagishita G.
October 11, 2022
The Inaugural lecture of Haruo Kasai in WPI-IRCN is uploaded in YouTube.
August 1, 2022
Ms. Rina Yamaguchi joiined Yagishita G as a technician.
April 1, 2022
Haruo Kasai is assigned as a project professor in WPI-IRCN.
April 1, 2022
Dr. Shoou Umemoto joined Yagishita G as postdoc.
March 16, 2022
Our lab is recruiting graduate students and postdocs.
March 14, 2022
March 3, 2022
The last lecture of Prof. Haruo Kasai in Faculty of Medicine will be delivered at Tetsumon-kodo and Zoom.
Nov. 24, 2021
July 1, 2021
Our review article on spine dynamics has published Nature Reviews Neuroscience.
May 15, 2021
Ms. Yuki Sakata has joined our lab!
April 15, 2021
Dr. Chinhua Chou joined Yagishita G. as a research fellow.
April 1, 2021
Mr Hidefumi Ohmi joined Yagishita G as a master course student.
March 16, 2021
Tomoki Arima has joined as a graduate student.
March 2, 2021
Dr. Fumihiro Eto has joined our lab!