業績一覧

  • Takahashi N., Iwatsubo T., Nakano I., Machinami R.
    Focal appearance of cerebellar torpedoes associated with discrete lesions in the cerebellar white matter.
    Acta Neuropathologica 84,153-6, 1992
  • Terauchi Y., Sakura H., Yasuda K., Iwamoto K., Takahashi N., Ito K., Kasai H., Suzuki H., Ueda O., Kameda N., Jishage K., Komeda K., Noda M., Kanazawa Y., Taniguchi S., Miwa I., Akanuma Y., Kodama T., Yazaki Y., Kadowaki T.
    Pancreatic β-cell specific targeted disruption of glucokinase gene.
    J. Biol. Chem. 270, 30253-6, 1995
  • Takahashi N., Kadowaki T., Yazaki Y., Miyashita Y., Kasai H.
    Multiple exocytotic pathways in pancreatic β-cells.
    J. Cell Biol. 138, 55-64, 1997
  • Takahashi N., Kadowaki T., Yazaki Y., Ellis-Davies G.C.R., Miyashita Y., Kasai H.
    Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells.
    Proc. Natl. Acad. Sci. U.S.A. 96, 760-5, 1999
  • Eto K., Tsubamoto Y., Terauchi Y., Sugiyama T., Kishimoto T., Takahashi N., Yamauchi N., Kubota N., Murayama S., Aizawa T., Akanuma Y., Aizawa S., Kasai H., Yazaki Y., Kadowaki T.
    Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion.
    Science 283, 981-5, 1999
  • Kasai H. & Takahashi N.
    Multiple kinetic components and the Ca2+ requirements of exocytosis.
    Phil. Trans. R. Soc. Lond. B 353, 1-5, 1999
  • Takahashi N., Kishimoto T., Nemoto T., Kadowaki T., Kasai H.
    Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet.
    Science 297, 1349-52, 2002
  • Takahashi N., Nemoto T., Kimura R., Tachikawa A., Miwa A., Okado H., Miyashita Y., Iino M., Kadowaki T., Kasai H.
    Two-photon excitation imaging of pancreatic islet with various fluorescent probes.
    Diabetes S51, S25-28, 2002
  • Kasai H., Suzuki T., Liu T.-T., Kishimoto T., Takahashi N.
    Fast and cAMP-sensitive mode of Ca2+-dependent exocytosis in pancreatic β cells.
    Diabetes S51, S19-24, 2002
  • Noda M., Yamashita S., Takahashi N., Eto K., Shen L., Izumi K., Daniel S., Tsubamoto Y., Nemoto T., Iino M., Kasai H., Sharp GWG., Kadowaki T.
    Switch to anaerobic glucose metabolism with NADH accumulation in the β-cell model of mitochondrial diabetes.
    J. Biol. Chem. 277, 41817-26, 2002
  • Takahashi N., Hatakeyama H., Okado H., Miwa A., Kishimoto T., Kojima T., Abe T., Kasai H.
    Sequential exocytosis of insulin granules is associated with redistribution of SNAP25.
    J. Cell Biol. 165, 255-62, 2004
  • Kasai K., Ohara-Imaizumi M., Takahashi N., Mizutani S., Zhao S., Kikuta T., Kasai H., Nagamatsu S., Gomi H., Izumi T.
    Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.
    J. Clin. Invest. 115, 388-96, 2005
  • Kasai H., Hatakeyama H., Kishimoto T., Liu T. T., Nemoto T., Takahashi N.
    A new quantitative (TEPIQ) analysis for diameters of exocytic vesicles and its application to mouse pancreatic islets.
    J. Physiol. 568, 891-903, 2005.
  • Kishimoto T., Liu T.T., Hatakeyama H., Nemoto T., Takahashi N., Kasai H.
    Sequential compound exocytosis of large dense-core vesicles in PC12 cells studied with TEPIQ analysis.
    J. Physiol. 568, 905-15, 2005
  • Liu T.T., Kishimoto T., Hatakeyama H., Nemoto T., Takahashi N. Kasai H.
    Exocytosis and endocytosis of small vesicle in PC12 cells studied with TEPIQ analysis.
    J. Physiol. 568, 917-29, 2005
  • Fukui K., Yang Q., Cao Y., Takahashi N., Hatakeyama H., Wang H., Wada J., Zhang Y., Marselli L., Nammo T., Yoneda K., Onishi M., Higashiyama S., Matsuzawa Y., Gonzalez F.J., Weir G.C., Kasai H., Shimomura I., Miyagawa J., Wollheim C.B., Yamagata K.
    The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation.
    Cell Metab. 2, 373-84, 2005
  • Hatakeyama H., Kishimoto T., Nemoto T., Kasai H., Takahashi N.
    Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets.
    J. Physiol. 570, 271-82, 2006
  • Miura A., Yamagata K., Kakei M, Hatakeyama H., Takahashi N., Fukui K., Nammo T., Yoneda K., Inoue Y., Sladek F.M., Magnuson M.A., Kasai H., Miyagawa J., Gonzalez F.J., Shimomura I.
    Hepatocyte nuclear factor-4α is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
    J. Biol. Chem. 281, 5246-57, 2006.
  • Kishimoto T., Kimura R., Liu T.T., Nemoto T., Takahashi N., Kasai H.
    Vacuolar sequential exocytosis of large dense-core vesicles in adrenal medulla.
    EMBO J. 25, 673-82, 2006.
  • Kasai H., Kishimoto T., Nemoto T., Hatakeyama H., Liu T.T., Takahashi N.
    Two-photon excitation imaging of exocytosis and endocytosis and determination of their spatial organization.
    Advanced Drug Delivery Reviews 58,850-77, 2006
  • Takahashi N. & Kasai H.
    Exocytic Process Analyzed with Two-photon Excitation Imaging in Endocrine Pancreas.
    Endocrine J. 54, 337-346, 2007
  • Hatakeyama H., Takahashi N., Kishimoto T., Nemoto T. and Kasai H.
    Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in beta-cells.
    J. Physiol. 582, 1087-98, 2007
  • Takahashi N. & Kasai H.
    Two-photon excitation imaging of insulin exocytosis. Seino S., Bell GI (ed.), Pancreatic beta cell in health and disease. Springer Verlag p195-211, 2007
  • Kasai H., Hatakeyama H., Ohno M., Takahashi N.
    Exocytosis in islet beta-cells. Md.S. Islam (ed.), The Islets of Langerhans, Advances in Experimental Medicine and Biology 654, p303-336
    Springer Science Business Media B.V. 2010
  • Takahashi N.*, Hatakeyama H., Okado H., Noguchi J., Ohno M., Kasai H*.
    SNARE conformational changes that prepare vesicles for exocytosis.
    Cell Metab. 12, 19-29, 2010
  • Kaneko K., Ueki K., Takahashi N., Hashimoto S., Okamoto M., Awazawa M., Okazaki Y., Ohsugi M., Inabe K., Umehara T., Yoshida M., Kakei M., Kitamura T., Luo J., Kulkarni R.N., Kahn C.R., Kasai H., Cantley L.C., Kadowaki T.
    Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms.
    Cell Metab. 12, 619-32, 2010
  • Cai T., Hirai H., Zhang G., Zhang M., Takahashi N., Kasai H., Satin L.S., Leapman R.D., Notkins A.L.
    Deletion of Ia-2 and/or Ia-2β in mice decreases insulin secretion by reducing the number of dense core vesicles.
    Diabetologia 54, 2347-57, 2011
  • Takahashi N.
    Two-photon imaging of insulin exocytosis in the pancreatic islets.
    Diabetology International 2, 112-21, 2011
  • Kimura Y., Momotake A., Takahashi N., Kasai H., Arai T.
    Polarity-dependent photophysical properties of hemicianine dyes and their application in 2-photon microscopy biological imaging.
    Chemistry Letters 41, 528-30, 2012
  • Kasai H., Takahashi N., Tokumaru H.
    Distinct initial SNARE configurations underlying the diversity of exocytosis.
    Physiol Rev 92, 1915-64, 2012
  • Lam PP, Ohno M, Dolai S, He Y, Qin T, Liang T, Zhu D, Kang Y, Liu Y, Kauppi M, Xie L, Wan WC, Bin NR, Sugita S, Olkkonen VM, Takahashi N., Kasai H, Gaisano HY.
    Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells.
    Diabetes 62, 2416-28, 2013
  • Hayama T., Noguchi J., Watanabe S., Takahashi N., Hayashi-Takagi A., Ellis-Davies GC., Matsuzaki M., Kasai H.
    GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.
    Nature Neuroscience 16, 1409-16, 2013
  • Takahashi N..
    Imaging Analysis of Insulin Secretion with Two-photon Microscopy.
    Biol Pharm Bull 38, 656-62, 2015
  • Takahashi N., Sawada W., Noguchi J., Watanabe S., Ucar H., Hayashi-Takagi A., Yagishita S., Ohno M., Tokumaru H., Kasai H.
    Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells
    Nature Communications 2015, DOI 10.1038/NCOMMS9531.
  • Komori N, Jakkampudi S, Motoishi R, Abe M, Kamada K, Furukawa K, Katan C, Sawada W, Takahashi N., Kasai H, Xue B, Kobayashi T.
    Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light.
    Chem Commun (Camb). 52, 331-4, 2016
  • Jakkampudi S., Abe M., Komori N., Takagi R., Furukawa K., Katan C., Sawada W., Takahashi N., Kasai H.
    Design and Synthesis of a 4-Nitrobromobenzene Derivative Bearing an Ethylene Glycol Tetraacetic Acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region and Their Application in vivo.
    ACS Omega. pp 193?201, 2016 DOI: 10.1021/acsomega.6b00119
  • Noguchi J., Hayama T., Watanabe S., Ucar H., Yagishita S., Takahashi N., Kasai H.
    State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines.
    Sci Rep. 6:32897, 2016 DOI: 10.1038/srep32897.
  • Kunii M., Ohara-Imaizumi M., Takahashi N., Kobayashi M., Kawakami R., Kondoh Y., Shimizu T., Simizu S., Lin B., Nunomura K., Aoyagi K., Ohno M., Ohmuraya M., Sato T., Yoshimura S.I., Sato K., Harada R., Kim Y.J., Osada H., Nemoto T., Kasai H., Kitamura T., Nagamatsu S., Harada A.
    Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.
    J Cell Biol. 215, 121-138, 2016
  • Qin T., Liang T., Zhu D., Kang Y., Xie L., Dolai S., Sugita S., Takahashi N., Ostenson C.G., Banks K., Gaisano H.Y.
    Munc18b increases insulin granule fusion, restoring deficient insulin secretion in type-2 diabetes human and Goto-Kakizaki rat islets with improvement in glucose homeostasis.
    EBioMedicine 16, 262-274, 2017.
  • 最近出版された和文総説

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