Publication List

Publication List

Publication List


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Noguchi, J., Hayama, T., Watanabe, S., Ucar, H., Yagishita, S., Takahashi, N. & Kasai, H. (2016).
State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines.
Scientific Reports 6: 32897.      DOI: 10.1038/srep32897

Nagaoka, A., Takehara, A., Hayashi-Takagi, A., Shirai, F., Ishii, K., Noguchi, J., Ichiki, K. & Kasai, H.(2016).
Enhancement of the intrinsic fluctuations of pdendritic spines in FMRP knock-out mice.
Scientific Reports 6: 26651.      DOI: 10.1038/srep26651

Kunii, M., Ohara-Imaizumi, M., Takahashi, N., Kobayashi, M., Kawakami, R.,  Kondoh, Y., Shimizu, T., Simizu, S., Lin, B., Nunomura, K., Aoyagi, K., Ohno, M., Ohmuraya, M., Sato, T., Yoshimura, S., Sato, K., Harada, R., Kim, Y.,   Osada, H., Nemoto, T., Kasai, H., Kitamura, T., Nagamatsu, S., & Harada, A.(2016).
Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.
Journal of Cell Biology 215(1):121-138. DOI:10.1083/jcb.201604030

Jakkampudi, S., Abe, M.*, Komori, N., Takagi, R., Furukawa, K., Katan, C.,  Sawada, W., Takahashi, N. & Kasai, H. (2016).
Design and Synthesis of a 4‑Nitrobromobenzene Derivative Bearing an Ethylene Glycol Tetraacetic Acid Unit for a New Generation of Caged Calcium Compounds with Two-Photon Absorption Properties in the Near-IR Region and Their Application in Vivo.  
ACS Omega 1(2): 193-201.  DOI: 10.1021/acsomega.6b00119

Takehara, H., Nagaoka, A., Noguchi, J., Akagi, T., Kasai, H. & Ichiki, T. (2016).
Implantable microfluidic device with hydrogel permeable membrane for delivering chemical compounds and imaging neural cells in living mice.
Journal of Photopolymer Science and Technology

Hayashi-Takagi, A., Yagishita, S., Nakamura, M. Shirai, F., Wu, Y., Loshbaugh, A.L., Kuhlman, B., Hahn, K.M. and Kasai, H. (2015).
Labelling and optical erasure of synaptic memory traces in the motor cortex.
Nature 525: 333-338. 

Takahashi, N., Sawada W, Noguchi, J., Watanabe, S., Ucar, H., Hayashi-Takagi, A., Yagishita, S., Ohno, M., Tokumaru, H. & Kasai, H. (2015).
Two-photon fluorescence lifetime imaging of primed SNARE complexes in presynaptic terminals and β cells.
Nature Communcations 6, 8531.

Komori, N., Jakkampudi, S., Motoishi, R., Abe, M., Kamada, K., Furukawa, K., Katan, C., Sawada, W., Takahashi, N., Kasai, H., Xue, B., Kobayashi, T. (2015).
Design and synthesis of a new chromophore, 2-(4-nitrophenyl)benzofuran, for two-photon uncaging using near-IR light.
Chemical Communications 52: 331-334.  DOI: 10.1039/C5CC07664A


Yagishita, S., Hayashi-Takagi, A., Ellis-Davies, G.C.R., Urakubo, H., Ishii, S., and Kasai, H. (2014).
A critical time window for dopamine actions on the structural plasticity of dendritic spines.
Science 345: 1616-1620.

Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S.G., Yan, Z., Kasai, H., Huganir, R.L., Campbell, D.A., Sawa, A. (2014).
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.
Proc. Natl. Acad. Sci. U.S.A. 111: 6461-6466.

Asrican, B, Augustine, G.J., Berglund, K., Chen, S., Chow, N. Deisseroth, K., Feng, G., Gloss, B. Hira, R., Hoffman, C., Kasai, K., Katarya, M., Jinsook, K., Kudolo, J., Lee, L., Qiang Lo, S., Mancuso, J., Matsuzaki, M., Nakajima, R., Qiu, L., Tan, T., Tang, Y., Ting, J.T., Tsuda, S. & Wen, L. (2013).
Next-generation transgenic mice for optogenetic analysis of neural circuits.
Frontier in Neural Circuits 7:160.

Takehara, H., Nagaoka, A., Noguchi, J., Akagi, T., Sakai, T., Chung, U., Kasai, H. & Ichiki, T. (2013).
Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology.
Biomicrofluidics 7:054109.

Hayama, T.*, Noguchi, J.*, Watanabe, S., Ellis-Davies, G.C.R., Hayashi, A., Takahashi, N., Matsuzaki, M. & Kasai, H. (2013).
GABA promotes the competitive selection of dendritic spines by controlling local Ca2+ signaling.
Nature Neurosci. 16:1409-1416. (* Equal contribution)

Lam, P.*, Ohno, M.*, , Subhankar, D.*, He, Y., Qin, T., Lian, T., Zhu, D., Kang, Y., Liu, Y., Kauppi, M., Xie, L., Wan, W., Bin, N., Sugita, S., Olkkonen, V., Takahashi,N., Kasai,H.CA & Gaisano,H.Y.CA (2013).
Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells.
Diabetes. 62:2416-2428. (* Equal contribution, CACorresponding authors.)

Hira, R., Ohkubo, F., Tanaka, Y.R., Masamizu, Y., Augustine, G.J., Kasai, H. & Matsuzaki, M. (2013).
In vivo optogenetic tracing of functional corticocortical connections between motor forelimb areas.
Frontier in Neural Circuits 7:55.

Hira, R., Ohkubo, F., Ozawa, K., Isomura, Y., Kitamura, K., Kano, M., Kasai, H., & Matsuzaki, M. (2013).
Spatial and temporal reconfiguration of microcircuitry activity in the motor cortex for voluntary movement.
J. Neurosci. 33:1377-1390.




Kasai, H., Takahashi, N. & Tokumaru, H. (2012).
Distinct initial SNARE configurations underlying the diversity of exocytosis.
Physiol. Rev. 92:1915-1964

Ogata, S., Miki, T., Seino, S., Tamai, S., Kasai, H. & Nemoto, T. (2012).
A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells.
PLoS ONE 7: e37048

Kimura, Y., Momotake, A., Takahashi, N., Kasai, H. & Arai, T. (2012).
Polarity-dependent photophysical properties of hemicyanine dyes and their application in 2-photon microscopy biological imaging.
Chemistry Letters 41:528-530

Matsuzaki, M., Ellis-Davies, G.C.R., Kanemoto, Y., & Kasai, H. (2011).
Simultaneous two-photon activation of presynaptic cells and calcium imaging in postsynaptic dendritic spines.
Neural Systems and Circuits 1:2.

Cai, T., Hirai, H., Zhang, G., Zhang, M., Takahashi, N., Kasai, H., Satin, L.S., Leapman, R.D. & Notkins, A.L. (2011).
Decreased in the number of dense core vesicles is responsible for the impaired secretion if insulin in IA-2 and IA-2? null mice.
Diabetologia, 54:2347-57.

Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M. & Kasai H. (2011).
In vivo two-photon uncaging of glutamate revealing the structure-function relationships o f dendritic spines in the neocortex of adult mice.
J.Physiol. 589: 2320-2329.

Kanemoto, Y., Matsuzaki, M., Morita, S., Hayama, T., Noguchi, J., Senda, N., Momotake, A., Arai, T., and Kasai, H. (2011).
Spatial distributions of GABA receptors and local inhibition of Ca2+ transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons.
PLoS ONE, 6: e22652.

Matsuzaki, M. and Kasai, H. (2011).
Two-Photon Uncaging Microscopy. Imaging in Neuroscience: A Laboratory Manual (eds.Helmchen and Konnerth).
CSHL Press, Cold Spring Harbor, NY,USA.

Ako, R., Wakimoto, M., Ebisu, H., Tanno, K., Hira, R., Kasai, H., Matsuzaki, M. and Kawasaki, H. (2011).
Simultaneous visualization of multiple neuronal properties with single-cell resolution in the living rodent brain.
Mol. Cell. Neurosci., 48:246-257.




Kasai, H., Hayama, T., Ishikawa, M., Watanabe, S. & Yagishita, S. (2010).
Learning rules and persistence of dendritic spines.
Eur. J. Neurosci. 32:241-249.

Takahashi, N., Hatakeyama, H., Okado, H., Noguchi, J. Ohno, M. & Kasai, H. (2010).
SNARE conformational changes that prepare vesicles for exocytosis.
Cell Metabolism 12:19-29.

Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A. & Noguchi, J. (2010).
Structural dynamics of dendritic spines in memory and cognition.
Trends Neurosci. 33, 121-129.

Matsuzaki, M. Hayama, T., Kasai, H. & Ellis-Davies, G.C.R. (2010)
Two photon uncaging of gamma-aminobutyric acid probes on neurons in intact brain tissue.
Nature Chemical Biology 6: 255-257.

Kantevari, S.*, Matsuzaki, M.*, Kanemoto, Y., Kasai, H.CA & Ellis-Davies, G.C.R.CA (2010). (* Equal contribution. CACorresponding authors.)
Two-color, two-photon uncaging of glutamate and GABA.
Nature Methods 7:123-125.

Kasai, H., Hatakeyama, H., Ohno, M. & Takahashi, N. (2010)
Exocytosis in islet beta-cells.
Advances in Experimental Medicine and Biology ("The Islet of Langerhans.") 654:303-336.

Obi, N., Momotake, A., Kanemoto, Y., Matsuzaki, M, Kasai, H. & Arai, T. (2010)
1-Acyl-5-methoxy-8-nitro-1,2-dihydroquinoline: A biologically useful photolabile precursor of carboxylic acids.
Tetrahedron letters 51:1642-1657.

Morita, S., Yasumatsu, N. Noguchi, J. & Kasai, H. (2009)
Generation, elimination and weight fluctuations of synapses in the cerebral cortex.
Communicative and Integrative Biology 2:1-4.

Hira, R., Honkura, N., Noguchi, J., Maruyama, Y., Augustine, G.J., Kasai, H., & Matsuzaki, M. (2009)
Transcranial optogenetic stimulation for functional mapping of the motor cortex.
J. Neurosci. Methods 179. 258-263.



Yasumatsu, N., Matsuzaki, M., Miyazaki, T., Noguchi, J. & Kasai, H. (2008)
Principles of long-term dynamics of dendritic spines.
J. Neurosci 28, 13592-13608.

Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies,G.C.R. & Kasai, H. (2008)
The subspine organization of actin fibers regulates the structure and plasticity of dendritic spines.
Neuron 57, 719-729.

Tanaka, J.*, Horiike, Y.*, Matsuzaki, M., Miyazaki, T., Ellis-Davies, GCR & Kasai, H. (2008) (* Equal contribution)
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines.
Science 319, 1683-1687.

Matsuzaki., M., Ellis-Davies, G.C.R. & Kasai, H. (2008)
Three-dimensional mapping of unitary synaptic connections by two-photon macro photolysis of caged glutamate.
J. Neurophysiol. 99, 1535-1544.

Takahashi, N. & Kasai, H. (2007)
Exocytic process analyzed with two-photon excitation imaging in endocrine pancreas.
Endocrine J. 54, 337-347.

Hatakeyama H, Takahashi N, Kishimoto T, Nemoto T & Kasai H (2007)
Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse beta-cells.
J. Physiol. 582, 1087-1098.

Ellis-Davies, G.C.R., Matsuzaki, M., Paukert, M., Kasai, H. & Bergles, D.E. (2007)
CDNI-Glu: an improved caged glutamate for expeditious ultraviolet and 2-photon photolysis in brain slices.
J. Neurosci. 27, 6601-4.

Matsuzaki, M. (2007)
Factors critical for the plasticity of dendritic spines and memory storage.
Neurosci. Res. 57, 1-9.

Wang, H.*, Peca, J.*, Matsusaki, M.*,Matsusaki, K., Noguchi, J., Qiu, L., Wang, D., Zhang, F., Boyden, E., Deisseroth, K., Kasai, H., Hall, W.C., Feng, G. & Augustine, G.J. (2007) (* Equal contribution)
High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice.
P.N.A.S. 104, 8143-8148.

Takahashi, N. & Kasai, H. (2007)
Two-photon excitation imaging of insulin exocytosis. In “ Pancreatic beta cell in health and disease.” Springer Verlag, New York 195-211.

Augustine, G.J. & Kasai, H. (2007)
Bernard Katz, quantal transmitter release, and the foundations of presynaptic physiology,
J. Physiol. (Lond.) 578, 623-625.


Kishimoto, T., Kimura, R., Liu.T.-T., Nemoto, T., Takahashi, N. & Kasai, H.(2006).
Vacuolar sequential excocytosis of large dense-core vesicles in adrenal medulla.
EMBO J. 25, 673-682

Hatakeyama, H., Kishimoto, T., Nemoto, T., Kasai, H., & Takahashi, N. (2006)
Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets.
J. Physiol. 570, 271-82.

Kasai, H., Kishimoto, T. Nemoto, T. Hatakeyama, H, Liu, T-T. & Takahashi, N. (2006)
Two-photon excitation imaging of exocytosis and endocytosis and determination of their spatial organization.
Adv. Drug Delivery Rev. 58, 850-877.

Miura A, Yamagata K, Kakei M, Hatakeyama H, Takahashi N, Fukui K, Nammo T, Yoneda K, Inoue Y, Sladek FM, Magnuson MA, Kasai H, Miyagawa J, Gonzalez FJ, & Shimomura I (2006).
Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
J. Biol. Chem. 281,5246-5257.

Fukui,K., Yang,Q., Cao,Y., Takahashi,N., Hatakeyama,H., Wang,H., Wada,J., Zhang,Y., Marselli,L., Nammo,T., Yoneda,K., Onishi,M., Higashiyama,S., Matsuzawa,Y., Gonzalez,F.J., Weir,G.C., Kasai,H., Shimomura,I., Miyagawa,J., Wollheim,C.B., & Yamagata,K.(2005)
The HNF-1 target Collectrin controls insulin exocytosis by SNARE complex formation.
Cell Metab. 2, 373-384.

Kasai‚H.‚ Hatakeyama‚H.‚ Kishimoto‚T.‚ Liu‚T.-T.‚ Nemoto‚T. & Takahashi‚ N. (2005)
A new quantitative (two-photon extracellular polar-tracer imaging-based quantification (TEPIQ)) analysis for diameters of exocytic vesicles and its application to mouse pancreatic islets.
J. Physiol. 568‚ 891-903.

Kishimoto‚T.‚ Liu‚T.-T.‚ Hatakeyama‚H.‚ Nemoto‚T.‚ Takahashi‚ N. & Kasai‚H. (2005)
Sequential compound exocytosis of large dense-core vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis.
J. Physiol. 568‚ 905-915.

Liu‚T.-T.‚ Kishimoto‚T.‚ Hatakeyama‚H.‚ Nemoto‚T.‚ Takahashi‚ N. & Kasai‚H. (2005)
Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis.
J. Physiol. 568‚ 917-929.

Ohkura‚M.‚ Matsuzaki‚M.‚ Kasai‚H.‚ Imoto‚K. & Nakai‚J. (2005)
Genetically encoded bright Ca2+ probe applicable for dynamic Ca2+ imaging of dendritic spines.
Analytical Chemistry 77‚ 5861-5869.

Noguchi,J., Matsuzaki,M., Ellis-Davies, G.C.R. & Kasai, H. (2005)
Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites.
Neuron 46, 609-622.

Hayakawa‚Y.‚ Nemoto‚T.‚ Iino‚M.‚ Kasai‚H.‚(2005)
Rapid Ca2+ -dependent increase in oxygen consumption by mitochondria in single mammalian central neurons.
Cell Calcium 37‚ 359-370.

Oshima‚A.‚ Kojima‚T.‚ Dejima‚K.‚ Hisa‚Y.‚ Kasai‚H.‚ & Nemoto‚T.‚(2005)
Two-photon microscopic analysis of acetylcholine-induced mucus secretion in guinea pig nasal glands.
Cell Calcium 37‚ 349-357

Kasai‚ K.‚ Ohara-Imaizumi‚ M.‚ Takahashi‚ N.‚ Mizutani‚ S.‚ Zhao‚ S.‚ Kikuta‚ T.‚ Kasai‚ H.‚ Nagamatsu‚ S.‚ Gomi‚ H.‚ Izumi‚ T. (2005)
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.
J. Clin. Invest. 115‚ 388-396.

Tanaka‚J.‚ Matsuzaki‚M.‚ Tarusawa‚E.‚ Momiyama‚A.‚ Molnar‚E.‚ Kasai‚H. & Shigemoto‚R. (2005)
Number and density of AMPA receptors in single synapses in immature cerebellum.
Journal of Neuroscience 25‚ 799-807.


Sakai‚N.‚ Tsubokawa‚H.‚ Matsuzaki‚M.‚ Kajimoto‚T.‚ Takahashi‚E.‚ Ren‚Y.‚ Ohmori‚S.‚ Shirai‚Y.‚ Matsubayashi‚H.‚ Chen‚J.‚ Duman‚RS.‚ Kasai‚H. & Saito‚N. (2004)
Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice.
Genes to Cells 9‚ 945-57.

Nemoto‚ T‚ Kojima‚ T‚ Oshima‚ A‚ Bito‚ H‚ & Kasai‚ H.(2004)
Stabilization of exocytosis by dynamic F-actin coating of zymogen granules in pancreatic acini.
J. Biol. Chem. 279‚ 37544-37550

Matsuzaki‚ M.‚ Honkura‚ N.‚ Ellis-Davies‚G.C.R.‚ & Kasai‚H. (2004)
Structural basis of long-term potentiation in single dendritic spines.
Nature 429‚ 761-766

Takahashi‚N.‚Hatakeyama‚H.‚Okado‚H.‚Miwa‚A.‚Kishimoto‚T.‚Kojima‚T.‚Abe‚T.& Kasai‚H. (2004).
Sequential exocytosis of insulin granules is associated with redistribution of SNAP25.
Journal of Cell Biology 165‚ 255-262.

Kasai‚ H.‚ Matsuzaki‚ M.‚ Noguchi‚ J.‚ Yasumatsu‚ N. & Nakahara‚ H. (2003).
Structure-stability-function relationships of dendritic spines.
Trends Neurosci. 26‚ 360-368.


Takahashi‚N.‚Kishimoto‚T.‚Nemoto‚T.‚Kadowaki‚T. & Kasai‚H. (2002).
Fusion pore dynamics & insulin granule exocytosis in the pancreatic islet.
Science 297‚1349-52.

Noda M.‚ Yamashita S.‚ Takahashi N.‚ Eto K.‚ Shen L.‚ Izumi K.‚ Daniel S.‚ Tsubamoto Y.‚ Nemoto T.‚ Iino M.‚ Kasai H.‚ Sharp GWG.‚ Kadowaki T. (2002).
Switch to anaerobic glucose metabolism with NADH accumulation in the β-cell model of mitochondrial diabetes.
J. Biol. Chem. 277‚ 41817-26.

Takahashi‚ N.‚ Nemoto‚ T.‚ Kimura‚ R.‚ Tachikawa‚ A.‚ Miwa‚ A.‚ Okado‚ H.‚ Miyashita‚ Y.‚ Iino‚ M.‚ Kadowaki‚ T.‚Kasai‚ H. (2002).
Two-photon excitation imaging of pancreatic islet with various fluorescent probes
Diabetes 51(S1)‚ S25-28.

Kasai‚ H.‚ Suzuki‚ T.‚ Liu‚ T.-T.‚ Kishimoto‚ T.‚ Takahashi. N. (2002).
Fast & cAMP-sensitive mode of Ca2+-dependent exocytosis in pancreatic β cells.
Diabetes 51(S1)‚ S19-24.

Matsuzaki‚ M.‚ Ellis-Davies‚ G.C.R.‚ Nemoto‚ T.‚ Miyashita‚ Y.‚ Iino‚ M.‚ Kasai‚ H. (2001).
Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
Nature Neuroscience 4‚ 1086-1092

Kishimoto‚ T.‚ Liu‚ T-T.‚ Ninomiya‚ Y.‚ Takagi‚ H.‚ Yoshioka‚ T.‚ Ellis-Davies‚ G.C.R.‚ Miyashita‚ Y.‚ Kasai‚ H.(2001).
Ion selectivities of the Ca2+ sensors for exocytosis in rat phaeochromocytoma cells
J.Physiol.(Lond) 533.3‚ 627-637.

Nemoto‚ T.‚ Kimura‚ R.‚ Ito‚ K.‚ Tachikawa‚ A.‚ Miyashita‚ Y. Iino‚ M.‚ Kasai‚ H. (2001)
Sequential replenishment mechanism of exocytosis in pancreatic acini.
Nature Cell Biol. 3‚ 253-258.


Maeda‚ H.‚ Ellis-Davies‚ G.C.R.‚ Ito‚ K.‚ Miyashita‚ Y. & Kasai‚ H. (1999).
Supralinear Ca2+ signaling by cooperative & mobile Ca2+ buffering in Purkinje neurons.
Neuron 24‚ 989-1002.

Kasai‚ H. (1999).
Comparative biology of Ca2+-dependent exocytosis: implications of kinetic diversity for secretory function.
Trends Neurosci. 22‚ 88-93.

Takahashi‚N.‚ Kadowaki‚ T.‚ Yazaki‚Y.‚ Ellis-Davies‚ G.C.R.‚ Miyashita‚ Y. & Kasai‚ H. (1999).
Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic β cells.
Proc. Natl. Acad. Sci. U.S.A. 96‚ 760-765.

Kasai‚ H. & Takahashi‚ N. (1999).
Multiple components of exocytosis & Ca2+ requirements.
Phil. Trans. R. Soc. Lond. B:Biol. Sci. 354‚ 331-335.

Kasai‚ H.‚ Kishimoto‚ T.‚ Liu‚ T-T.‚ Miyashita‚ Y.‚ Podini‚P.‚ Grohovaz‚ F. & Meldolesi‚ J. (1999).
Mutiple & diverse forms of regulated exocytosis revealed in wild-type & defective PC12 cells.
Proc. Natl. Acad. Sci. U.S.A. 96‚ 945-949.

Eto‚ K.‚ Tsubamoto‚ Y.‚ Terauchi‚ Y.‚ Sugiyama‚ T.‚ Kishimoto‚ T.‚ Takahashi‚ N.‚ Yamauchi‚ N.‚ Kubota‚ N.‚ Murayama‚ S.‚ Aizawa‚ T.‚ Akanuma‚Y.‚ Aizawa‚ S.‚ Kasai‚ H.‚ Yazaki‚ Y. & Kadowaki‚ T. (1999).
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism & insulin secretion.
Science 283‚ 981-985.

Ito‚ K.‚ Miyashita‚ Y. & Kasai‚ H. (1999).
Kinetic control of multiple forms of Ca2+ spikes by inositol trisphosphate in pancreatic acinar cells.
J. Cell Biol. 146‚ 405-414.

Eto‚ K.‚ Suga‚S.‚ Wakui‚M.‚ Tsubamoto‚Y.‚ Terauchi‚Y.‚Taka‚ J.‚ Aizawa‚ S.‚ Noda‚M.‚ Kimura‚ S.‚ Kasai‚ H. & Kadowaki‚ T. (1999).
NADH shuttle system regulates KATP channel-dependent pathway & steps distal to cytosolic Ca2+ concentration elevation in glucose-induced insulin secretion.
J. Biol. Chem. 1999 Sept 3 274(36). 25386-25393.

Kasai‚ H. (1998).
Ca2+ dependent exocytosis in endocrine‚ exocrine & non-secretory cells.
Kor. J. Physiol. Pharmac. 2‚ 1-7.


Ito‚ K.‚ Miyashita‚ Y. & Kasai‚ H. (1997).
Micromolar & submicromolar Ca2+ spikes regulating distinct cellular functions in pancreatic acinar cells.
EMBO J. 16‚ 242-251.

Sjoedin‚ L.‚ Ito‚ K.‚ Miyashita‚ Y. & Kasai‚ H. (1997).
Cytoplasmic Ca2+ gradients evoked by acetylcholine & peptides in pancreatic acinar cells of the guinea pig.
Pflug. Arch. 433‚ 397-402.

Ninomiya‚ Y.‚ Kishimoto‚ T.‚ Yamazawa‚ T.‚ Ikeda‚ H.‚ Miyashita‚ Y. & Kasai‚ H. (1997).
Kinetic diversity in the fusion of exocytotic vesicles.
EMBO J. 16‚ 929-934.

Takahashi‚ N.‚ Kadowaki‚ T.‚ Yazaki‚ Y.‚ Miyashita‚ Y. & Kasai‚ H. (1997).
Multiple exocytotic pathways in pancreatic β-cells.
J. Cell Biol. 138‚ 55-64.

Kasai‚ H.‚ Takagi‚ H.‚ Ninomiya‚ Y.‚ Kishimoto‚ T.‚ Yosida‚ A.‚ Yoshioka‚ T. & Miyashita‚ Y. (1996).
Two components of exocytosis & endocytosis in phaeochromocytoma cells studied using caged-Ca2+ compounds.
J. Physiol. 494‚ 53-65.

Ninomiya‚ Y.‚ Kishimoto‚ T.‚ Miyashita‚ Y. & Kasai‚ H. (1996).
Ca2+-dependent exocytotic pathways in Chinese hamster ovary fibroblast revealed by capacitace measurement & caged-Ca2+ compound.
J. Biol. Chem. 271‚ 17751-17754.

Kasai‚ H. & Petersen‚ O.H.P. (1996).
"Neuronal Ca2+ signalling."
Seminar in Neuroscience 8. p259.


Kasai‚ H. (1995).
Pancreatic Ca2+ waves & secretion. In Calcium waves‚ gradients & oscillations. Wiley‚
Chichester (Ciba Foundation Symposium 188) p104-120.

Terauchi‚ Y.‚ Sakura‚ H.‚ Yasuda‚ K.‚ Iwamoto‚ K.‚ Takahashi‚ N.‚ Ito‚ K.‚ Kasai‚ H.‚ Suzuki‚ H.‚ Ueda‚ O.‚ Kamada‚ N.‚ Jishage‚ K.‚ Komeda‚ K.‚ Noda‚ M.‚ Kanazawa‚ Y.‚ Taniguchi‚ S.‚ Miwa‚ I.‚ Akanuma‚ Y.‚ Kodama‚ T.‚ Yazaki‚ Y. & Kadowaki‚ T. (1995).
Pancreatic β-cell-specific targeted disruption of glucokinase gene.
J. Biol. Chem. 270‚ 30253-30256.

Mori‚ A.‚ Takahashi‚ T.‚ Miyashita‚ Y. & Kasai‚ H. (1994).
Two distinct glutamatergic synaptic inputs to the striatal medium spiny neurones of neonatal rat & paired-pulse depression.
J. Physiol. 476‚217-228.

Petersen‚ O.H.‚ Petersen‚ C. & Kasai‚ H. (1994).
Calcium & hormone action.
Ann. Rev. Physiol. 56‚ 297-319.

Kasai‚ H. & Petersen‚ O.H. (1994).
Spatial dynamics of second messengers: IP3 & cAMP as long range & associative messengers.
Trends Neurosci 17‚ 95-101.

Mori‚ A.‚ Takahashi‚ T.‚ Miyashita‚ Y. & Kasai‚ H. (1994).
Quantal properties of S-type glutamatergic synaptic input to the striatal medium spiny neurons from neonate rat.
Neurosci. Lett. 169‚ 199-202.

Mori‚ A.‚ Takahashi‚ T.‚ Miyashita‚ Y. & Kasai‚ H. (1994).
Quantal properties of H-type glutamatergic synaptic input to the striatal medium spiny neurons.
Br. Res. 654‚ 177-179.

Iino‚ M.‚ Kasai‚ H. & Yamazawa‚ T. (1994).
Visualization of neural control of intracellular Ca2+ concentration in single vascular smooth muscle cells in situ.
EMBO J. 13‚ 5026-5031.


Kasai‚ H. (1993).
Cytosolic Ca2+ gradients‚ Ca2+ binding proteins & synaptic plasticity.
Neurosci. Res. 16‚ 1-7.

Maruyama‚ Y.‚ Inooka‚ G.‚ Li‚ Y.‚ Miyashita‚ Y. & Kasai‚ H. (1993).
Agonist-induced localized Ca2+ spikes directly triggerring exocytotic secretion in exocrine pancreas.
EMBO J. 12‚ 3017-22.

Kasai‚ H.‚ Li‚ Y. & Miyashita‚ Y. (1993).
Subcellular distribution of Ca2+ release channels underlying Ca2+ waves & oscillations in exocrine pancreas.
Cell 74‚ 669-677.

Iino‚ M.‚ Yamazawa‚ T.‚ Miyashita‚ Y.‚ Endo‚ M. & Kasai‚ H. (1993).
Critical intracellular Ca2+ concentration for all-or-none Ca2+ spiking in single smooth muscle cells.
EMBO J. 12‚ 5287-5291.

Kasai‚ H.‚ Mori‚ A.‚ Takahashi‚ T. & Miyashita‚ Y. (1993).
Quantal properties of single glutamatergic synaptic boutons in thin slices from rat neostriatum.
Ann. NY Acad. Sci. 707‚ 458-460.

Kasai‚ H. & Neher‚ E. (1992).
Dihydropyridine-sensitive & omega-conotoxin-sensitive calcium channels in a mammalian neuroblastoma-glioma cell line.
J. Physiol. 448‚ 161-188.

Kasai‚ H. (1992).
Voltage- & time-dependent inhibition of neuronal calcium channels by a GTP-binding protein in a mammalian cell line.
J. Physiol. 448‚ 189-209.


Kasai‚ H. & Augustine‚ G. J. (1990).
Cytosolic Ca2+ gradients triggering unidirectional fluid secretion in exocrine pancreas.
Nature 348‚ 735-738.

Kasai‚ H. (1991).
Tonic inhibition & rebound facilitation of a neuronal calcium channel by a GTP-binding protein.
Proc. Natl. Acad. Sci. U.S.A. 88‚ 8855-8859.


Aosaki‚ T. & Kasai‚ H. (1989).
Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons.
Pflug. Arch. 414‚ 150-156.

Kasai‚ H. & Aosaki‚ H. (1989).
Modulation of Ca-channel current by an adenosine analog mediated by a GTP-binding protein in chick sensory neurons.
Pflug. Arch. 414‚ 145-149.

Kasai‚ H. & Aosaki‚ T. (1988).
Divalent cation dependent inactivation of the high-voltage-activated Ca-channel currents in chick sensory neurons.
Pflug. Arch. 411‚ 695-697.

Kasai‚ H.‚ Fukuda‚ J. & Segawa‚ K. (1987).
Transformation of glial cells in mouse embryonic brain cells in vitro with simian virus 40.
Neurosci. Lett. 76‚ 239-235.

Kasai‚ H.‚ Aosaki‚ T. & Fukuda‚ J. (1987).
Presynaptic Ca-antagonist omega-conotoxin irreversibly blocks N-type Ca-channels in chick sensory neurons.
Neurosci. Res. 4‚ 228-235.

Kasai‚ H.‚ Kameyama‚ M.‚ Yamaguchi‚ K. & Fukuda‚ J. (1986).
Single transient K channels in mammalian sensory neurons.
Biophys. J‚ 49‚ 1243-1247.

Toyama‚ K.‚ Fukii‚ K.‚ Kasai‚ H. & Maeda‚ K. (1986).
The resposiveness of Clare-Bishop neurons to size cues for motion streopsis.
Neurosci. Res. 4‚ 110-128.

Toyama‚ K.‚ Komatsu‚ Y.‚ Kasai‚ H.‚ Fujii‚ K. & Umetani‚ K. (1985).
Responsiveness of Clare-Bishop neurons to visual cues associated with motion of a visual stimulus in the three-dimensional space.
Vision Res. 25‚ 407-414.

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